The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) belongs to the „Forschungsverbund Berlin e. V. (FVB)“. The FVB is an institution of seven natural sciences research institutes in Berlin funded by the Federal Republic of Germany and the association of its federal states. The research institutes are members of the Leibniz association.
In the group Physiology und Pathology of Ion Transport (led by Prof. Thomas Jentsch; FMP / MDC Berlin) there is an opening for a
in Cell Biology / Physiology (f/m/d)
In ERC- and DFG-funded projects, we investigate the structure-function, cell biology and physiology of anion channels, both in cell culture and in newly generated genetic mouse models in highly innovate projects. These are focused mainly on the newly identified ASOR/TMEM206 and VRAC/LRRC8 anion channels. Intriguingly, VRAC channels not only transport chloride, but also organic molecules including neurotransmitters, messengers involved in innate immunity, and drugs. We are just beginning to unravel the role of the ‘novel’ acid-activated ASOR/TMEM206 channel which plays a role in stroke and likely has important roles in the endosomal/lysosomal system like other anion channels we have been studying. Our previous studies with CLC anion transporters revealed unexpected roles of vesicular anion transport in endocytosis and lysosomal function, as evident from mouse and human pathologies resulting from their disruption.
We are an international, highly interdisciplinary team with a strong interest in the role of anion channels in the physiology and pathology of various organs, including e.g. endocrine or immune cells, the brain and the kidney.
We are looking for a postdoctoral researcher highly motivated and excited to unravel novel roles of anion transport in cellular and organismal function. After our breakthroughs in molecularly identifying novel anion channels, we have developed many mouse models and other tools. These now put us into a unique position to discover new physiology and disease mechanisms, and this in various different organs. The current postdoctoral project will focus on the role of vesicular anion transport on endolysosomal function, initially in cells of the immune system. The project will address crucial cell biological questions from a very novel angle.
The educational background of the candidate should be in natural sciences, including, but not limited to, biology, biochemistry, biophysics or medicine. A thorough background in cell biology and physiology is a prerequisite for this position, as is previous hands-on experience in standard techniques of molecular cell biology or morphology. Although the project may focus on a particular organ, the ideal candidate will be broadly interested in several areas of cell biology and physiology, such as neurobiology, nephrology, or immunology, as our research - depending on the transporter under study - may impact many different organs. Our lab is fully equipped for cell biology and morphology, as well as for electrophysiology. It is part of both the FMP and MDC with their excellent facilities (e.g. advanced optical microscopy, EM, mass spec, screening unit, etc.).
The position is available immediately. Initially, it is limited to 2 years with an option for extension.
Salaries will be based on the German salary scale TVöD Bund. We offer equal opportunities regardless of gender and welcome applications of disabled candidates. They will be preferred in case of equal qualification. We welcome applications from all backgrounds.
Visit our webpage http://www.fmp-berlin.de/jentsch.html to know more about our lab.
On the FMP homepage please go to “Stellenangebote/Jobs” and click first on this advertisement and then on the button “Online bewerben”. Please combine your application documents including motivation letter, CV, names and contacts of references and copies of degree certificates into a single pdf file and submit as soon as possible but not later than October 15th, 2021.
We are looking forward to your application!
Selected recent publications:
Voss F.K., Ullrich F., Münch J., Lazarow K., Lutter D., Mah N., Andrade-Navarro M.A., von Kries J.P., Stauber T., Jentsch T.J. (2014). Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Science 344, 634638.
Stuhlmann T., Planells-Cases R., Jentsch T.J. (2018). LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion. Nature Communications 9, 1974
Ullrich F., Blin S., Lazarow K., Daubitz T., von Kries J.P., Jentsch T.J. (2019). Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels. eLife 8.
Göppner C., Orozco I.J., Hoegg-Beiler M.B., Soria A.H., Hübner C.A., Fernandes-Rosa F.L., Boulkroun S., Zennaro M.C., Jentsch T.J. (2019). Pathogenesis of hypertension in a mouse model for CLCN2-related hyperaldosteronism. Nature Communications 10, 4678.
Zhou C.§, Chen X.§, Planells-Cases R.§, Chu J., …. Qiu Z. *, Jentsch T.J. *, Xiao H.* (2020).Transfer of cGAMP into bystander cells by LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity. Immunity 52, 767-781.